


Pituitary adenomas (PA), or pituitary neuroendocrine tumors (PitNETs), represent 15% of all central nervous system tumors. Classic description of PitNETs solely by hormonal classification has given way to key transcription factors that play a role in the pathology of PitNETs including steroidogenic factor-1 (SF-1), t-box pituitary transcription factor (TPIT), and pituitary transcription factor 1 (PIT-1).

Germline mutations in various familial PitNETs are discussed including those in familial isolated pituitary adenoma (FIPA), multiple endocrine neoplasia (MEN), neurofibromatosis 1 (NF1), and Carney complex. Mighty Mike is a trademark of Pangea Software, Inc.Recent advances in next generation sequencing have improved insight into the pathogenesis of PitNETs. The demo will only let you play the first 3 levels and it will time bomb after about an hour of play.įor other questions, send email to Pangea Software, Inc. When you register the game, it will allow you to play all 15 levels. This copy of the game will play in a demo mode until you pay the shareware fee and are assigned a registration number. The full version of Mighty Mike may be downloaded by clicking here. Mighty Mike will NOT RUN ON ANY INTEL-BASED MAC. You should download and test it out first before buying it to be sure it will run on your system. It might work in Classic mode on OS X, but it might not. To answer a commonly asked question: No, there are no cheap upgrades to Mighty Mike for owners of the original version of Power Pete. Now that we have re-acquired the rights to the game, we have decided to re-release it as shareware for only $15.

Mighty Mike is the game formerly known as Power Pete which was originally published by MacPlay back in 1995.
